Burano's lace-making tradition became prominent in the 1500s, when the island's artisans developed a technique that would shape fashion across Europe for two centuries. The distinctive method, known as "punto in aria" (points in the air), involved creating lace stitched entirely onto itself using only a needle and thread, with no underlying fabric or bobbin framework as support. The result was lace of extraordinary delicacy and complexity, light enough to seem suspended in air, which is precisely what the name describes.

Dogaressa Morosina Morosini Grimani, wife of Doge Marino Grimani, established the first organized workshop, employing 130 women in what became a significant source of income for the island. Demand for Burano lace spread rapidly across European courts. Louis XIV of France wore Burano lace at his coronation, a commission that reportedly took two years to complete. The French king's finance minister, Jean-Baptiste Colbert, recognized the economic value flowing out of France to Venice and took decisive action: in 1665, he induced approximately 200 Buranella lace-makers to relocate to France, where they taught French workers the craft. The result was "Point de France," which eventually became a competing tradition, though connoisseurs maintained that the Venetian original retained a fineness the French version never quite matched.

The fall of the Venetian Republic in 1797 ended the institutional support that had sustained commercial lace production, and the craft entered a long decline. By the mid-19th century, punto in aria had nearly vanished from Burano. The revival came through a convergence of crisis and determination. During the devastating winter of 1872, which froze the lagoon and left fishing families destitute, Countess Andriana Marcello organized a campaign to restore lace-making as an economic lifeline for the island. The effort was possible because one elderly woman, Francesca Memo, known by her nickname "Cencia Scarpaiola," still possessed mastery of the punto in aria technique. Cencia became the central figure in the revival, passing her knowledge to a new generation of students at the Scuola di Merletti (Lace School), which opened in 1872 in Piazza Galuppi. By 1875, the school had enrolled over 100 students, and Burano lace was once again finding buyers across Europe.

The Lace School operated for over a century, training generations of merlettaie (lace-makers) and preserving pattern books that documented hundreds of traditional designs. In 1981, the school's collection became the foundation of the Museo del Merletto (Lace Museum), which displays historical pieces alongside demonstrations of technique. The museum closed for renovation and reopened on June 25, 2011, with an expanded collection that traces the full arc of Burano's lace-making tradition from the Renaissance to the present. Today, authentic handmade Burano lace requires months of painstaking work and commands prices that reflect the skill involved. Visitors should be aware that much of what is sold on the island is machine-made or imported; the genuine article is available from a handful of artisans and the museum shop.